The effect of dose on the safety and immunogenicity of the VSV Ebola candidate vaccine: a randomised double-blind, placebo-controlled phase 1/2 trial

BACKGROUND: Safe and effective vaccines against Ebola could prevent or control outbreaks. The safe use of replication-competent vaccines requires a careful dose-selection process. We report the first safety and immunogenicity results in volunteers receiving 3 × 10(5) plaque-forming units (pfu) of th...

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Publicado en:Lancet Infect Dis
Main Authors: Huttner, Angela, Dayer, Julie-Anne, Yerly, Sabine, Combescure, Christophe, Auderset, Floriane, Desmeules, Jules, Eickmann, Markus, Finckh, Axel, Goncalves, Ana Rita, Hooper, Jay W, Kaya, Gürkan, Krähling, Verena, Kwilas, Steve, Lemaître, Barbara, Matthey, Alain, Silvera, Peter, Becker, Stephan, Fast, Patricia E, Moorthy, Vasee, Kieny, Marie Paule, Kaiser, Laurent, Siegrist, Claire-Anne
Formato: Artigo
Idioma:Inglês
Publicado: 2019
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6624136/
https://ncbi.nlm.nih.gov/pubmed/26248510
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/S1473-3099(15)00154-1
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