Phase 1 Trials of rVSV Ebola Vaccine in Africa and Europe

BACKGROUND: The replication-competent recombinant vesicular stomatitis virus (rVSV)–based vaccine expressing a Zaire ebolavirus (ZEBOV) glycoprotein was selected for rapid safety and immunogenicity testing before its use in West Africa. METHODS: We performed three open-label, dose-escalation phase 1...

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Publicat a:N Engl J Med
Autors principals: Agnandji, S.T., Huttner, A., Zinser, M.E., Njuguna, P., Dahlke, C., Fernandes, J.F., Yerly, S., Dayer, J.-A., Kraehling, V., Kasonta, R., Adegnika, A.A., Altfeld, M., Auderset, F., Bache, E.B., Biedenkopf, N., Borregaard, S., Brosnahan, J.S., Burrow, R., Combescure, C., Desmeules, J., Eickmann, M., Fehling, S.K., Finckh, A., Goncalves, A.R., Grobusch, M.P., Hooper, J., Jambrecina, A., Kabwende, A.L., Kaya, G., Kimani, D., Lell, B., Lemaître, B., Lohse, A.W., Massinga-Loembe, M., Matthey, A., Mordmüller, B., Nolting, A., Ogwang, C., Ramharter, M., Schmidt-Chanasit, J., Schmiedel, S., Silvera, P., Stahl, F.R., Staines, H.M., Strecker, T., Stubbe, H.C., Tsofa, B., Zaki, S., Fast, P., Moorthy, V., Kaiser, L., Krishna, S., Becker, S., Kieny, M.-P., Bejon, P., Kremsner, P.G., Addo, M.M., Siegrist, C.-A.
Format: Artigo
Idioma:Inglês
Publicat: 2015
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5490784/
https://ncbi.nlm.nih.gov/pubmed/25830326
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1056/NEJMoa1502924
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