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Structural and mutational analysis of the ribosome-arresting human XBP1u
XBP1u, a central component of the unfolded protein response (UPR), is a mammalian protein containing a functionally critical translational arrest peptide (AP). Here, we present a 3 Å cryo-EM structure of the stalled human XBP1u AP. It forms a unique turn in the ribosomal exit tunnel proximal to the...
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| 出版年: | eLife |
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| 主要な著者: | , , , , , , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
eLife Sciences Publications, Ltd
2019
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6624018/ https://ncbi.nlm.nih.gov/pubmed/31246176 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.46267 |
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