Structural and mutational analysis of the ribosome-arresting human XBP1u

XBP1u, a central component of the unfolded protein response (UPR), is a mammalian protein containing a functionally critical translational arrest peptide (AP). Here, we present a 3 Å cryo-EM structure of the stalled human XBP1u AP. It forms a unique turn in the ribosomal exit tunnel proximal to the...

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Vydáno v:eLife
Hlavní autoři: Shanmuganathan, Vivekanandan, Schiller, Nina, Magoulopoulou, Anastasia, Cheng, Jingdong, Braunger, Katharina, Cymer, Florian, Berninghausen, Otto, Beatrix, Birgitta, Kohno, Kenji, von Heijne, Gunnar, Beckmann, Roland
Médium: Artigo
Jazyk:Inglês
Vydáno: eLife Sciences Publications, Ltd 2019
Témata:
Biochemistry and Chemical Biology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6624018/
https://ncbi.nlm.nih.gov/pubmed/31246176
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.46267
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