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Both Microtubule-Stabilizing and Microtubule-Destabilizing Drugs Inhibit Hypoxia-Inducible Factor-1α Accumulation and Activity by Disrupting Microtubule Function

We have recently identified a mechanistic link between disruption of the microtubule cytoskeleton and inhibition of tumor angiogenesis via the hypoxia-inducible factor-1 (HIF-1) pathway. Based on this model, we hypothesized that other microtubule-targeting drugs may have a similar effect on HIF-1α....

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Bibliografiske detaljer
Udgivet i:Cancer Res
Main Authors: Escuin, Daniel, Kline, Erik R., Giannakakou, Paraskevi
Format: Artigo
Sprog:Inglês
Udgivet: 2005
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6623969/
https://ncbi.nlm.nih.gov/pubmed/16204076
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-04-4095
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