Sphingolipid Storage Affects Autophagic Metabolism of the Amyloid Precursor Protein and Promotes Aβ Generation

Deposition of amyloid β peptides (Aβs) in extracellular amyloid plaques within the human brain is a hallmark of Alzheimer's disease (AD). Aβ derives from proteolytic processing of the amyloid precursor protein (APP) by β- and γ-secretases. The initial cleavage by β-secretase results in shedding...

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Publicado no:J Neurosci
Main Authors: Tamboli, Irfan Y., Hampel, Heike, Tien, Nguyen T., Tolksdorf, Karen, Breiden, Bernadette, Mathews, Paul M., Saftig, Paul, Sandhoff, Konrad, Walter, Jochen
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2011
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6623751/
https://ncbi.nlm.nih.gov/pubmed/21289194
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.2954-10.2011
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