A Signaling Cascade of Nuclear Calcium-CREB-ATF3 Activated by Synaptic NMDA Receptors Defines a Gene Repression Module That Protects against Extrasynaptic NMDA Receptor-Induced Neuronal Cell Death and Ischemic Brain Damage

Synapse-to-nucleus signaling triggered by synaptic NMDA receptors can lead to the buildup of a neuroprotective shield. Nuclear calcium activating the cAMP response element binding protein (CREB) plays a key role in neuroprotection acquired by synaptic activity. Here we show that in mouse hippocampal...

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Vydáno v:J Neurosci
Hlavní autoři: Zhang, Sheng-Jia, Buchthal, Bettina, Lau, David, Hayer, Stefanie, Dick, Oliver, Schwaninger, Markus, Veltkamp, Roland, Zou, Ming, Weiss, Ursula, Bading, Hilmar
Médium: Artigo
Jazyk:Inglês
Vydáno: Society for Neuroscience 2011
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6622995/
https://ncbi.nlm.nih.gov/pubmed/21451036
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.2672-10.2011
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