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Therapeutic targeting of the pathological triad of extrasynaptic NMDA receptor signaling in neurodegenerations

Activation of extrasynaptic N-methyl-d-aspartate (NMDA) receptors causes neurodegeneration and cell death. The disease mechanism involves a pathological triad consisting of mitochondrial dysfunction, loss of integrity of neuronal structures and connectivity, and disruption of excitation–transcriptio...

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Vydáno v:J Exp Med
Hlavní autor: Bading, Hilmar
Médium: Artigo
Jazyk:Inglês
Vydáno: The Rockefeller University Press 2017
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5339681/
https://ncbi.nlm.nih.gov/pubmed/28209726
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20161673
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