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Therapeutic targeting of the pathological triad of extrasynaptic NMDA receptor signaling in neurodegenerations
Activation of extrasynaptic N-methyl-d-aspartate (NMDA) receptors causes neurodegeneration and cell death. The disease mechanism involves a pathological triad consisting of mitochondrial dysfunction, loss of integrity of neuronal structures and connectivity, and disruption of excitation–transcriptio...
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| Udgivet i: | J Exp Med |
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| Hovedforfatter: | |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
The Rockefeller University Press
2017
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5339681/ https://ncbi.nlm.nih.gov/pubmed/28209726 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20161673 |
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