Targeting of Monomer/Misfolded SOD1 as a Therapeutic Strategy for Amyotrophic Lateral Sclerosis

There is increasing evidence that toxicity of mutant superoxide dismutase-1 (SOD1) in amyotrophic lateral sclerosis (ALS) is linked to its propensity to misfold and to aggregate. Immunotargeting of differently folded states of SOD1 has provided therapeutic benefit in mutant SOD1 transgenic mice. The...

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Udgivet i:J Neurosci
Main Authors: Liu, Hsueh-Ning, Tjostheim, Sonja, DaSilva, Kevin, Taylor, David, Zhao, Beibei, Rakhit, Rishi, Brown, Mary, Chakrabartty, Avijit, McLaurin, JoAnne, Robertson, Janice
Format: Artigo
Sprog:Inglês
Udgivet: Society for Neuroscience 2012
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Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6622344/
https://ncbi.nlm.nih.gov/pubmed/22745481
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.5053-11.2012
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