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PI3-kinase/Akt Pathway-Regulated Membrane Insertion of Acid-Sensing Ion Channel 1a Underlies BDNF-Induced Pain Hypersensitivity

Central neural plasticity plays a key role in pain hypersensitivity. This process is modulated by brain-derived neurotrophic factor (BDNF) and also involves the type 1a acid-sensing ion channel (ASIC1a). However, the interactions between the BDNF receptor, tropomyosin-related kinase B (TrkB), and AS...

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Bibliografiske detaljer
Udgivet i:J Neurosci
Main Authors: Duan, Bo, Liu, Di-Shi, Huang, Yu, Zeng, Wei-Zheng, Wang, Xiang, Yu, Hui, Zhu, Michael X., Chen, Zhe-Yu, Xu, Tian-Le
Format: Artigo
Sprog:Inglês
Udgivet: Society for Neuroscience 2012
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6622133/
https://ncbi.nlm.nih.gov/pubmed/22553040
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.4479-11.2012
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