Cdk5/p25-Induced Cytosolic PLA2-Mediated Lysophosphatidylcholine Production Regulates Neuroinflammation and Triggers Neurodegeneration

The deregulation of cyclin-dependent kinase 5 (Cdk5) by p25 has been shown to contribute to the pathogenesis in a number of neurodegenerative diseases such as amyotrophic lateral sclerosis (ALS), Parkinson's disease (PD) and Alzheimer's disease (AD). In particular, p25/Cdk5 has been shown...

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Udgivet i:J Neurosci
Main Authors: Sundaram, Jeyapriya R., Chan, Elizabeth S., Poore, Charlene P., Pareek, Tej K., Cheong, Wei Fun, Shui, Guanghou, Tang, Ning, Low, Chian-Ming, Wenk, Markus R., Kesavapany, Sashi
Format: Artigo
Sprog:Inglês
Udgivet: Society for Neuroscience 2012
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Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6621136/
https://ncbi.nlm.nih.gov/pubmed/22262900
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.5177-11.2012
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