Triterpenoid modulation of IL-17 and Nrf-2 expression ameliorates neuroinflammation and promotes remyelination in autoimmune encephalomyelitis

Inflammatory cytokines and endogenous anti-oxidants are variables affecting disease progression in multiple sclerosis (MS). Here we demonstrate the dual capacity of triterpenoids to simultaneously repress production of IL-17 and other pro-inflammatory mediators while exerting neuroprotective effects...

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Autori principali: Pareek, Tej K., Belkadi, Abdelmadjid, Kesavapany, Sashi, Zaremba, Anita, Loh, Sook L., Bai, Lianhua, Cohen, Mark L., Meyer, Colin, Liby, Karen T., Miller, Robert H., Sporn, Michael B., Letterio, John J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 2011
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3242013/
https://ncbi.nlm.nih.gov/pubmed/22355716
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep00201
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