Specific Inhibition of p25/Cdk5 Activity by the Cdk5 Inhibitory Peptide Reduces Neurodegeneration In Vivo

The aberrant hyperactivation of Cyclin-dependent kinase 5 (Cdk5), by the production of its truncated activator p25, results in the formation of hyperphosphorylated tau, neuroinflammation, amyloid deposition, and neuronal death in vitro and in vivo. Mechanistically, this occurs as a result of a neuro...

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Detalhes bibliográficos
Publicado no:J Neurosci
Main Authors: Sundaram, Jeyapriya Raja, Poore, Charlene Priscilla, Sulaimee, Noor Hazim Bin, Pareek, Tej, Asad, A.B.M.A., Rajkumar, Ramamoorthy, Cheong, Wei Fun, Wenk, Markus R., Dawe, Gavin Stewart, Chuang, Kai-Hsiang, Pant, Harish C., Kesavapany, Sashi
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2013
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6618624/
https://ncbi.nlm.nih.gov/pubmed/23283346
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.3593-12.2013
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