FBL2 Regulates Amyloid Precursor Protein (APP) Metabolism by Promoting Ubiquitination-Dependent APP Degradation and Inhibition of APP Endocytosis

The ubiquitin–proteasome pathway is a major protein degradation pathway whose dysfunction is now widely accepted as a cause of neurodegenerative diseases, including Alzheimer's disease. Here we demonstrate that the F-box and leucine rich repeat protein2 (FBL2), a component of the E3 ubiquitin l...

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Publicado en:J Neurosci
Autores principales: Watanabe, Tomomichi, Hikichi, Yukiko, Willuweit, Antje, Shintani, Yasushi, Horiguchi, Takashi
Formato: Artigo
Lenguaje:Inglês
Publicado: Society for Neuroscience 2012
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Articles
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6621050/
https://ncbi.nlm.nih.gov/pubmed/22399757
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.5659-11.2012
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