Differential Association of Receptor-Gβγ Complexes with β-Arrestin2 Determines Recycling Bias and Potential for Tolerance of Delta Opioid Receptor Agonists

Opioid tendency to generate analgesic tolerance has been previously linked to biased internalization. Here, we assessed an alternative possibility; whether tolerance of delta opioid receptor agonists (DORs) could be related to agonist-specific recycling. A first series of experiments revealed that D...

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Detalhes bibliográficos
Publicado no:J Neurosci
Main Authors: Audet, Nicolas, Charfi, Iness, Mnie-Filali, Ouissame, Amraei, Mohammad, Chabot-Doré, Anne-Julie, Millecamps, Magali, Stone, Laura S., Pineyro, Graciela
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2012
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6620903/
https://ncbi.nlm.nih.gov/pubmed/22492038
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.3734-11.2012
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