Ligand- and cell-dependent determinants of internalization and cAMP modulation by delta opioid receptor (DOR) agonists

Signaling bias refers to G protein-coupled receptor ligand ability to preferentially activate one type of signal over another. Bias to evoke signaling as opposed to sequestration has been proposed as a predictor of opioid ligand potential for generating tolerance. Here we measured whether delta opio...

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Hauptverfasser: Charfi, Iness, Nagi, Karim, Mnie-Filali, Ouissame, Thibault, Dominic, Balboni, Gianfranco, Schiller, Peter W., Trudeau, Louis-Eric, Pineyro, Graciela
Format: Artigo
Sprache:Inglês
Veröffentlicht: Springer Basel 2013
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3952036/
https://ncbi.nlm.nih.gov/pubmed/24022593
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00018-013-1461-7
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