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Identifying ligand-specific signalling within biased responses: focus on δ opioid receptor ligands
Opioids activate GPCRs to produce powerful analgesic actions but at the same time induce side effects and generate tolerance, which restrict their clinical use. Reducing this undesired response profile has remained a major goal of opioid research and the notion of ‘biased agonism’ is raising increas...
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| Vydáno v: | Br J Pharmacol |
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| Hlavní autoři: | , , , |
| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
Blackwell Publishing Ltd
2015
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4292958/ https://ncbi.nlm.nih.gov/pubmed/24665881 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.12705 |
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