Myocardial hypothermia increases autophagic flux, mitochondrial mass and myocardial function after ischemia-reperfusion injury

Animal studies have demonstrated beneficial effects of therapeutic hypothermia on myocardial function, yet exact mechanisms remain unclear. Impaired autophagy leads to heart failure and mitophagy is important for mitigating ischemia/reperfusion injury. This study aims to investigate whether the bene...

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Enregistré dans:
Détails bibliographiques
Publié dans:Sci Rep
Auteurs principaux: Marek-Iannucci, Stefanie, Thomas, Amandine, Hou, Jean, Crupi, Annunziata, Sin, Jon, Taylor, David J., Czer, Lawrence S., Esmailian, Fardad, Mentzer, Robert M., Andres, Allen M., Gottlieb, Roberta A.
Format: Artigo
Langue:Inglês
Publié: Nature Publishing Group UK 2019
Sujets:
Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6620356/
https://ncbi.nlm.nih.gov/pubmed/31292486
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-46452-w
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