Myocardial hypothermia increases autophagic flux, mitochondrial mass and myocardial function after ischemia-reperfusion injury

Animal studies have demonstrated beneficial effects of therapeutic hypothermia on myocardial function, yet exact mechanisms remain unclear. Impaired autophagy leads to heart failure and mitophagy is important for mitigating ischemia/reperfusion injury. This study aims to investigate whether the bene...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Marek-Iannucci, Stefanie, Thomas, Amandine, Hou, Jean, Crupi, Annunziata, Sin, Jon, Taylor, David J., Czer, Lawrence S., Esmailian, Fardad, Mentzer, Robert M., Andres, Allen M., Gottlieb, Roberta A.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6620356/
https://ncbi.nlm.nih.gov/pubmed/31292486
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-46452-w
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