The molecular nature of the 17β-Estradiol binding site in the voltage- and Ca(2+)-activated K(+) (BK) channel β1 subunit

The accessory β1 subunit modulates the Ca(2+)- and voltage-activated K(+) (BK) channel gating properties mainly by increasing its apparent Ca(2+) sensitivity. β1 plays an important role in the modulation of arterial tone and blood pressure by vascular smooth muscle cells (SMCs). 17β-estradiol (E2) i...

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Vydáno v:Sci Rep
Hlavní autoři: Granados, Sara T., Castillo, Karen, Bravo-Moraga, Felipe, Sepúlveda, Romina V., Carrasquel-Ursulaez, Willy, Rojas, Maximiliano, Carmona, Emerson, Lorenzo-Ceballos, Yenisleidy, González-Nilo, Fernando, González, Carlos, Latorre, Ramón, Torres, Yolima P.
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2019
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6620312/
https://ncbi.nlm.nih.gov/pubmed/31292456
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-45942-1
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