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Toxin-mediated ribosome stalling reprograms the Mycobacterium tuberculosis proteome

Mycobacterium tuberculosis readily adapts to survive a wide range of assaults by modifying its physiology and establishing a latent tuberculosis (TB) infection. Here we report a sophisticated mode of regulation by a tRNA-cleaving toxin that enlists highly selective ribosome stalling to recalibrate t...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Barth, Valdir C., Zeng, Ju-Mei, Vvedenskaya, Irina O., Ouyang, Ming, Husson, Robert N., Woychik, Nancy A.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6620280/
https://ncbi.nlm.nih.gov/pubmed/31292443
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-10869-8
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