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Growth and Translation Inhibition through Sequence-specific RNA Binding by Mycobacterium tuberculosis VapC Toxin

The Mycobacterium tuberculosis genome harbors an unusually large number of toxin-antitoxin (TA) modules. Curiously, over half of these are VapBC (virulence-associated protein) family members. Nonetheless, the cellular target, precise mode of action, and physiological role of the VapC toxins in this...

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Detalhes bibliográficos
Main Authors: Sharp, Jared D., Cruz, Jonathan W., Raman, Sahadevan, Inouye, Masayori, Husson, Robert N., Woychik, Nancy A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3339977/
https://ncbi.nlm.nih.gov/pubmed/22354968
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.340109
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