VapC Toxins from Mycobacterium tuberculosis Are Ribonucleases that Differentially Inhibit Growth and Are Neutralized by Cognate VapB Antitoxins

The chromosome of Mycobacterium tuberculosis (Mtb) encodes forty seven toxin-antitoxin modules belonging to the VapBC family. The role of these modules in the physiology of Mtb and the function(s) served by their expansion are unknown. We investigated ten vapBC modules from Mtb and the single vapBC...

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Hauptverfasser: Ahidjo, Bintou Ahmadou, Kuhnert, Diane, McKenzie, Joanna L., Machowski, Edith E., Gordhan, Bhavna G., Arcus, Vickery, Abrahams, Garth L., Mizrahi, Valerie
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2011
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3126847/
https://ncbi.nlm.nih.gov/pubmed/21738782
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0021738
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