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Structure of the DNA-Bound Spacer Capture Complex of a Type II CRISPR-Cas System

CRISPR and associated Cas proteins function as an adaptive immune system in prokaryotes to combat bacteriophage infection. During the immunization step, new spacers are acquired by the CRISPR machinery, but the molecular mechanism of spacer capture remains enigmatic. We show that the Cas9, Cas1, Cas...

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Detalhes bibliográficos
Publicado no:Mol Cell
Main Authors: Wilkinson, Martin, Drabavicius, Gediminas, Silanskas, Arunas, Gasiunas, Giedrius, Siksnys, Virginijus, Wigley, Dale B.
Formato: Artigo
Idioma:Inglês
Publicado em: Cell Press 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6620040/
https://ncbi.nlm.nih.gov/pubmed/31080012
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2019.04.020
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