PML–RARα induces all-trans retinoic acid-dependent transcriptional activation through interaction with MED1

Transcriptional activation by PML–RARα, an acute promyelocytic leukemia-related oncofusion protein, requires pharmacological concentrations of all-trans retinoic acid (ATRA). However, the mechanism by which the liganded PML–RARα complex leads to the formation of the preinitiation complex has been un...

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Publicado en:Transcription
Main Authors: Fukuoka, Tomoya, Kawai, Asami, Takahara, Taku, Mori, Mahiro, Roeder, Robert G., Hasegawa, Natsumi, Ito, Mitsuhiro
Formato: Artigo
Idioma:Inglês
Publicado: Taylor & Francis 2019
Assuntos:
Research Paper
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6619921/
https://ncbi.nlm.nih.gov/pubmed/31135261
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/21541264.2019.1624467
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