Postnatal Disruption of the Disintegrin/Metalloproteinase ADAM10 in Brain Causes Epileptic Seizures, Learning Deficits, Altered Spine Morphology, and Defective Synaptic Functions

The metalloproteinase ADAM10 is of importance for Notch-dependent cortical brain development. The protease is tightly linked with α-secretase activity toward the amyloid precursor protein (APP) substrate. Increasing ADAM10 activity is suggested as a therapy to prevent the production of the neurotoxi...

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Publicado no:J Neurosci
Main Authors: Prox, Johannes, Bernreuther, Christian, Altmeppen, Hermann, Grendel, Jasper, Glatzel, Markus, D'Hooge, Rudi, Stroobants, Stijn, Ahmed, Tariq, Balschun, Detlef, Willem, Michael, Lammich, Sven, Isbrandt, Dirk, Schweizer, Michaela, Horré, Katrien, De Strooper, Bart, Saftig, Paul
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2013
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6619719/
https://ncbi.nlm.nih.gov/pubmed/23926248
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.5910-12.2013
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