The Endocannabinoid 2-Arachidonoylglycerol Negatively Regulates Habituation by Suppressing Excitatory Recurrent Network Activity and Reducing Long-Term Potentiation in the Dentate Gyrus

Endocannabinoids are known to mediate retrograde suppression of synaptic transmission, modulate synaptic plasticity, and influence learning and memory. The 2-arachidonoylglycerol (2-AG) produced by diacylglycerol lipase α (DGLα) is regarded as the major endocannabinoid that causes retrograde synapti...

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Bibliographic Details
Published in:J Neurosci
Main Authors: Sugaya, Yuki, Cagniard, Barbara, Yamazaki, Maya, Sakimura, Kenji, Kano, Masanobu
Format: Artigo
Language:Inglês
Published: Society for Neuroscience 2013
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6619537/
https://ncbi.nlm.nih.gov/pubmed/23426686
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.3141-12.2013
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