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On the differences between mega‐ and meta‐imputation and analysis exemplified on the genetics of age‐related macular degeneration

While current genome‐wide association analyses often rely on meta‐analysis of study‐specific summary statistics, individual participant data (IPD) from multiple studies increase options for modeling. When multistudy IPD is available, however, it is unclear whether this data is to be imputed and mode...

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Dettagli Bibliografici
Pubblicato in:Genet Epidemiol
Autori principali: Gorski, Mathias, Günther, Felix, Winkler, Thomas W., Weber, Bernhard H. F., Heid, Iris M.
Natura: Artigo
Lingua:Inglês
Pubblicazione: John Wiley and Sons Inc. 2019
Soggetti:
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6619271/
https://ncbi.nlm.nih.gov/pubmed/31016765
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/gepi.22204
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