Selective Regulation of GluA Subunit Synthesis and AMPA Receptor-Mediated Synaptic Function and Plasticity by the Translation Repressor 4E-BP2 in Hippocampal Pyramidal Cells

The eukaryotic initiation factor 4E-binding protein-2 (4E-BP2) is a repressor of cap-dependent mRNA translation and a major downstream effector of the mammalian target of rapamycin (mTOR) implicated in hippocampal long-term synaptic plasticity and memory. Yet, synaptic mechanisms regulated by 4E-BP2...

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Veröffentlicht in:J Neurosci
Hauptverfasser: Ran, Israeli, Gkogkas, Christos G., Vasuta, Cristina, Tartas, Maylis, Khoutorsky, Arkady, Laplante, Isabel, Parsyan, Armen, Nevarko, Tatiana, Sonenberg, Nahum, Lacaille, Jean-Claude
Format: Artigo
Sprache:Inglês
Veröffentlicht: Society for Neuroscience 2013
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Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6619136/
https://ncbi.nlm.nih.gov/pubmed/23365227
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.3264-12.2013
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