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Dual Cleavage of Neuregulin 1 Type III by BACE1 and ADAM17 Liberates Its EGF-Like Domain and Allows Paracrine Signaling
Proteolytic shedding of cell surface proteins generates paracrine signals involved in numerous signaling pathways. Neuregulin 1 (NRG1) type III is involved in myelination of the peripheral nervous system, for which it requires proteolytic activation by proteases of the ADAM family and BACE1. These p...
Gardado en:
Publicado en: | J Neurosci |
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Main Authors: | , , , , , , , , , , , , , , |
Formato: | Artigo |
Idioma: | Inglês |
Publicado: |
Society for Neuroscience
2013
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Assuntos: | |
Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6618983/ https://ncbi.nlm.nih.gov/pubmed/23637177 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.3372-12.2013 |
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