Dual Cleavage of Neuregulin 1 Type III by BACE1 and ADAM17 Liberates Its EGF-Like Domain and Allows Paracrine Signaling

Proteolytic shedding of cell surface proteins generates paracrine signals involved in numerous signaling pathways. Neuregulin 1 (NRG1) type III is involved in myelination of the peripheral nervous system, for which it requires proteolytic activation by proteases of the ADAM family and BACE1. These p...

Descrizione completa

Salvato in:
Dettagli Bibliografici
Pubblicato in:J Neurosci
Autori principali: Fleck, Daniel, van Bebber, Frauke, Colombo, Alessio, Galante, Chiara, Schwenk, Benjamin M., Rabe, Linnea, Hampel, Heike, Novak, Bozidar, Kremmer, Elisabeth, Tahirovic, Sabina, Edbauer, Dieter, Lichtenthaler, Stefan F., Schmid, Bettina, Willem, Michael, Haass, Christian
Natura: Artigo
Lingua:Inglês
Pubblicazione: Society for Neuroscience 2013
Soggetti:
Articles
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6618983/
https://ncbi.nlm.nih.gov/pubmed/23637177
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.3372-12.2013
Tags: Aggiungi Tag
Nessun Tag, puoi essere il primo ad aggiungerne! !

Documenti analoghi