Dual Cleavage of Neuregulin 1 Type III by BACE1 and ADAM17 Liberates Its EGF-Like Domain and Allows Paracrine Signaling

Proteolytic shedding of cell surface proteins generates paracrine signals involved in numerous signaling pathways. Neuregulin 1 (NRG1) type III is involved in myelination of the peripheral nervous system, for which it requires proteolytic activation by proteases of the ADAM family and BACE1. These p...

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Publicado en:J Neurosci
Autores principales: Fleck, Daniel, van Bebber, Frauke, Colombo, Alessio, Galante, Chiara, Schwenk, Benjamin M., Rabe, Linnea, Hampel, Heike, Novak, Bozidar, Kremmer, Elisabeth, Tahirovic, Sabina, Edbauer, Dieter, Lichtenthaler, Stefan F., Schmid, Bettina, Willem, Michael, Haass, Christian
Formato: Artigo
Lenguaje:Inglês
Publicado: Society for Neuroscience 2013
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6618983/
https://ncbi.nlm.nih.gov/pubmed/23637177
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.3372-12.2013
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