Critical Role of Increased PTEN Nuclear Translocation in Excitotoxic and Ischemic Neuronal Injuries

Stroke is the leading cause of disability in developed countries. However, no treatment is available beyond 3 h post-ictus. Here, we report that nuclear translocation of PTEN (phosphatase and tensin homolog deleted on chromosome TEN) is a delayed step causatively leading to excitotoxic (in vitro) an...

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Pubblicato in:J Neurosci
Autori principali: Zhang, Shu, Taghibiglou, Changiz, Girling, Kimberly, Dong, Zhifang, Lin, Shinn-Zong, Lee, Wei, Shyu, Woei-cherng, Wang, Yu Tian
Natura: Artigo
Lingua:Inglês
Pubblicazione: Society for Neuroscience 2013
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Articles
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6618960/
https://ncbi.nlm.nih.gov/pubmed/23637190
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.5661-12.2013
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