MicroRNAs Regulate Human Brain Endothelial Cell-Barrier Function in Inflammation: Implications for Multiple Sclerosis

Blood–brain barrier (BBB) dysfunction is a major hallmark of many neurological diseases, including multiple sclerosis (MS). Using a genomics approach, we defined a microRNA signature that is diminished at the BBB of MS patients. In particular, miR-125a-5p is a key regulator of brain endothelial tigh...

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Publicado en:J Neurosci
Autores principales: Reijerkerk, Arie, Lopez-Ramirez, M. Alejandro, van het Hof, Bert, Drexhage, Joost A.R., Kamphuis, Wouter W., Kooij, Gijs, Vos, Joost B., van der Pouw Kraan, Tineke C.T.M., van Zonneveld, Anton J., Horrevoets, Anton J., Prat, Alexandre, Romero, Ignacio A., de Vries, Helga E.
Formato: Artigo
Lenguaje:Inglês
Publicado: Society for Neuroscience 2013
Materias:
Brief Communications
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6618888/
https://ncbi.nlm.nih.gov/pubmed/23595744
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.3965-12.2013
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