Sphingosine 1-phosphate receptor 5 mediates the immune quiescence of the human brain endothelial barrier

BACKGROUND: The sphingosine 1-phosphate (S1P) receptor modulator FTY720P (Gilenya®) potently reduces relapse rate and lesion activity in the neuroinflammatory disorder multiple sclerosis. Although most of its efficacy has been shown to be related to immunosuppression through the induction of lymphop...

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Main Authors: van Doorn, Ruben, Lopes Pinheiro, Melissa A, Kooij, Gijs, Lakeman, Kim, van het Hof, Bert, van der Pol, Susanne MA, Geerts, Dirk, van Horssen, Jack, van der Valk, Paul, van der Kam, Elizabeth, Ronken, Eric, Reijerkerk, Arie, de Vries, Helga E
Formato: Artigo
Idioma:Inglês
Publicado: BioMed Central 2012
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Research
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3425155/
https://ncbi.nlm.nih.gov/pubmed/22715976
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1742-2094-9-133
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