Sphingosine 1-phosphate receptor 5 mediates the immune quiescence of the human brain endothelial barrier

BACKGROUND: The sphingosine 1-phosphate (S1P) receptor modulator FTY720P (Gilenya®) potently reduces relapse rate and lesion activity in the neuroinflammatory disorder multiple sclerosis. Although most of its efficacy has been shown to be related to immunosuppression through the induction of lymphop...

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Detalhes bibliográficos
Main Authors: van Doorn, Ruben, Lopes Pinheiro, Melissa A, Kooij, Gijs, Lakeman, Kim, van het Hof, Bert, van der Pol, Susanne MA, Geerts, Dirk, van Horssen, Jack, van der Valk, Paul, van der Kam, Elizabeth, Ronken, Eric, Reijerkerk, Arie, de Vries, Helga E
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2012
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3425155/
https://ncbi.nlm.nih.gov/pubmed/22715976
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1742-2094-9-133
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