Astroglial PGC-1alpha increases mitochondrial antioxidant capacity and suppresses inflammation: implications for multiple sclerosis

Recent evidence suggests that reactive oxygen species (ROS) produced by inflammatory cells drive axonal degeneration in active multiple sclerosis (MS) lesions by inducing mitochondrial dysfunction. Mitochondria are endowed with a variety of antioxidant enzymes, including peroxiredoxin-3 and thioredo...

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Enregistré dans:
Détails bibliographiques
Publié dans:Acta Neuropathol Commun
Auteurs principaux: Nijland, Philip G, Witte, Maarten E, van het Hof, Bert, van der Pol, Susanne, Bauer, Jan, Lassmann, Hans, van der Valk, Paul, de Vries, Helga E, van Horssen, Jack
Format: Artigo
Langue:Inglês
Publié: BioMed Central 2014
Sujets:
Research
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4268800/
https://ncbi.nlm.nih.gov/pubmed/25492529
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40478-014-0170-2
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