Astroglial PGC-1alpha increases mitochondrial antioxidant capacity and suppresses inflammation: implications for multiple sclerosis

Recent evidence suggests that reactive oxygen species (ROS) produced by inflammatory cells drive axonal degeneration in active multiple sclerosis (MS) lesions by inducing mitochondrial dysfunction. Mitochondria are endowed with a variety of antioxidant enzymes, including peroxiredoxin-3 and thioredo...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:Acta Neuropathol Commun
Main Authors: Nijland, Philip G, Witte, Maarten E, van het Hof, Bert, van der Pol, Susanne, Bauer, Jan, Lassmann, Hans, van der Valk, Paul, de Vries, Helga E, van Horssen, Jack
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2014
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4268800/
https://ncbi.nlm.nih.gov/pubmed/25492529
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40478-014-0170-2
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados