Small-Fiber Neuropathy Na(v)1.8 Mutation Shifts Activation to Hyperpolarized Potentials and Increases Excitability of Dorsal Root Ganglion Neurons

Idiopathic small-fiber neuropathy (I-SFN), clinically characterized by burning pain in distal extremities and autonomic dysfunction, is a disorder of small-caliber nerve fibers of unknown etiology with limited treatment options. Functional variants of voltage-gated sodium channel Na(v)1.7, encoded b...

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Detalhes bibliográficos
Publicado no:J Neurosci
Main Authors: Huang, Jianying, Yang, Yang, Zhao, Peng, Gerrits, Monique M., Hoeijmakers, Janneke G.J ., Bekelaar, Kim, Merkies, Ingemar S.J., Faber, Catharina G., Dib-Hajj, Sulayman D., Waxman, Stephen G.
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2013
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6618513/
https://ncbi.nlm.nih.gov/pubmed/23986244
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.2710-13.2013
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