Small-Fiber Neuropathy Na(v)1.8 Mutation Shifts Activation to Hyperpolarized Potentials and Increases Excitability of Dorsal Root Ganglion Neurons

Idiopathic small-fiber neuropathy (I-SFN), clinically characterized by burning pain in distal extremities and autonomic dysfunction, is a disorder of small-caliber nerve fibers of unknown etiology with limited treatment options. Functional variants of voltage-gated sodium channel Na(v)1.7, encoded b...

Celý popis

Uloženo v:
Podrobná bibliografie
Vydáno v:J Neurosci
Hlavní autoři: Huang, Jianying, Yang, Yang, Zhao, Peng, Gerrits, Monique M., Hoeijmakers, Janneke G.J ., Bekelaar, Kim, Merkies, Ingemar S.J., Faber, Catharina G., Dib-Hajj, Sulayman D., Waxman, Stephen G.
Médium: Artigo
Jazyk:Inglês
Vydáno: Society for Neuroscience 2013
Témata:
Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6618513/
https://ncbi.nlm.nih.gov/pubmed/23986244
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.2710-13.2013
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!

Podobné jednotky