Intra- and interfamily phenotypic diversity in pain syndromes associated with a gain-of-function variant of Na(V)1.7

BACKGROUND: Sodium channel Na(V)1.7 is preferentially expressed within dorsal root ganglia (DRG), trigeminal ganglia and sympathetic ganglion neurons and their fine-diamter axons, where it acts as a threshold channel, amplifying stimuli such as generator potentials in nociceptors. Gain-of-function m...

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Autores principales: Estacion, Mark, Han, Chongyang, Choi, Jin-Sung, Hoeijmakers, Janneke GJ, Lauria, Giuseppe, Drenth, Joost PH, Gerrits, Monique M, Dib-Hajj, Sulayman D, Faber, Catharina G, Merkies, Ingemar SJ, Waxman, Stephen G
Formato: Artigo
Lenguaje:Inglês
Publicado: BioMed Central 2011
Materias:
Research
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3248882/
https://ncbi.nlm.nih.gov/pubmed/22136189
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1744-8069-7-92
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