Joint Effect of Insulin Signaling Genes on Insulin Secretion and Glucose Homeostasis

CONTEXT: Reduced insulin signaling in insulin secreting β-cells causes defective insulin secretion and hyperglycemia in mice. OBJECTIVE: We investigated whether functional polymorphisms affecting insulin signaling (ie, ENPP1 K121Q, rs1044498; IRS1 G972R, rs1801278; and TRIB3 Q84R, rs2295490) exert a...

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Detalhes bibliográficos
Publicado no:J Clin Endocrinol Metab
Main Authors: Prudente, Sabrina, Morini, Eleonora, Marselli, Lorella, Baratta, Roberto, Copetti, Massimiliano, Mendonca, Christine, Andreozzi, Francesco, Chandalia, Manisha, Pellegrini, Fabio, Bailetti, Diego, Alberico, Federica, Shah, Hetal, Abate, Nicola, Sesti, Giorgio, Frittitta, Lucia, Marchetti, Piero, Doria, Alessandro, Trischitta, Vincenzo
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2013
Assuntos:
JCEM Online: Advances in Genetics - Brief Report
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6618023/
https://ncbi.nlm.nih.gov/pubmed/23633196
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/jc.2012-4282
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