The IRS-1 G972R polymorphism and Type 2 Diabetes: a paradigm for the difficult ascertainment of the contribution to disease susceptibility of “low frequency-low risk” variants

AIMS AND HYPOTHESIS: Results on the association between the IRS-1 G972R polymorphism and type 2 diabetes have been conflicting. To obtain further insights onto this topic, we performed a meta-analysis of all available case-control studies. METHODS: Meta-analysis of 32 studies (12,076 cases and 11,28...

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Hlavní autoři: Morini, E., Prudente, S., Succurro, E., Chandalia, M., Zhang, Y.-Y., Mammarella, S., Pellegrini, F., Powers, C., Proto, V., Dallapiccola, B., Cama, A., Sesti, G., Abate, N., Doria, A., Trischitta, V.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2009
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2782547/
https://ncbi.nlm.nih.gov/pubmed/19557384
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00125-009-1426-4
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