Multiple Interactions Between Cancer Cells and the Tumor Microenvironment Modulate TRAIL Signaling: Implications for TRAIL Receptor Targeted Therapy

Tumor necrosis factor (TNF) related apoptosis-inducing ligand (TRAIL) signaling is far more complex than initially anticipated and can lead to either anti- or protumorigenic effects, hampering the successful clinical use of therapeutic TRAIL receptor agonists. Cell autonomous resistance mechanisms h...

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Vydáno v:Front Immunol
Hlavní autoři: de Looff, Margot, de Jong, Steven, Kruyt, Frank A. E.
Médium: Artigo
Jazyk:Inglês
Vydáno: Frontiers Media S.A. 2019
Témata:
Immunology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6617985/
https://ncbi.nlm.nih.gov/pubmed/31333662
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2019.01530
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