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Blockade of TGF-β signaling to enhance the antitumor response is accompanied by dysregulation of the functional activity of CD4(+)CD25(+)Foxp3(+) and CD4(+)CD25(−)Foxp3(+) T cells
BACKGROUND: The pleiotropic cytokine, transforming growth factor (TGF)-β, and CD4(+)CD25(+)Foxp3(+) regulatory T cells (Tregs) play a critical role in actively suppressing antitumor immune responses. Evidence shows that TGF-β produced by tumor cells promotes tolerance via expansion of Tregs. Our gro...
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| Publicado no: | J Transl Med |
|---|---|
| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
BioMed Central
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6617864/ https://ncbi.nlm.nih.gov/pubmed/31288845 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12967-019-1967-3 |
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