Quantitative Systems Pharmacology: An Exemplar Model‐Building Workflow With Applications in Cardiovascular, Metabolic, and Oncology Drug Development

Quantitative systems pharmacology (QSP), a mechanistically oriented form of drug and disease modeling, seeks to address a diverse set of problems in the discovery and development of therapies. These problems bring a considerable amount of variability and uncertainty inherent in the nonclinical and c...

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Veröffentlicht in:CPT Pharmacometrics Syst Pharmacol
Hauptverfasser: Helmlinger, Gabriel, Sokolov, Victor, Peskov, Kirill, Hallow, Karen M., Kosinsky, Yuri, Voronova, Veronika, Chu, Lulu, Yakovleva, Tatiana, Azarov, Ivan, Kaschek, Daniel, Dolgun, Artem, Schmidt, Henning, Boulton, David W., Penland, Robert C.
Format: Artigo
Sprache:Inglês
Veröffentlicht: John Wiley and Sons Inc. 2019
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Reviews
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6617832/
https://ncbi.nlm.nih.gov/pubmed/31087533
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/psp4.12426
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