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Expression of a fragment of Ankyrin 2 disrupts the structure of the Axon Initial Segment and causes axonal degeneration in Drosophila

Neurodegenerative stimuli are often associated with perturbation of the axon initial segment (AIS), but it remains unclear whether AIS disruption is causative for neurodegeneration or is a downstream step in disease progression. Here we demonstrate that either of two separate, genetically parallel p...

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Detalhes bibliográficos
Publicado no:Mol Neurobiol
Main Authors: Spurrier, Joshua, Shukla, Arvind Kumar, Buckley, Tyler, Smith-Trunova, Svetlana, Kuzina, Irina, Gu, Qun, Giniger, Edward
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6616013/
https://ncbi.nlm.nih.gov/pubmed/30666562
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s12035-019-1477-6
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