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Calcineurin-dependent dephosphorylation of the transcription factor CrzA at specific sites controls conidiation, stress tolerance, and virulence of Aspergillus fumigatus

Calcium signaling through calcineurin and its major transcription factor, CrzA, is integral to hyphal growth, stress response, and virulence of the pathogenic fungus Aspergillus fumigatus, the leading etiology of invasive aspergillosis. Dephosphorylation of CrzA by calcineurin activates the transcri...

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Bibliografiske detaljer
Udgivet i:Mol Microbiol
Main Authors: Shwab, E. Keats, Juvvadi, Praveen R., Waitt, Greg, Soderblom, Erik J., Barrington, Blake C., Asfaw, Yohannes G., Moseley, M. Arthur, Steinbach, William J.
Format: Artigo
Sprog:Inglês
Udgivet: 2019
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6615987/
https://ncbi.nlm.nih.gov/pubmed/30927289
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/mmi.14254
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