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Calcineurin-dependent dephosphorylation of the transcription factor CrzA at specific sites controls conidiation, stress tolerance, and virulence of Aspergillus fumigatus

Calcium signaling through calcineurin and its major transcription factor, CrzA, is integral to hyphal growth, stress response, and virulence of the pathogenic fungus Aspergillus fumigatus, the leading etiology of invasive aspergillosis. Dephosphorylation of CrzA by calcineurin activates the transcri...

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Détails bibliographiques
Publié dans:Mol Microbiol
Auteurs principaux: Shwab, E. Keats, Juvvadi, Praveen R., Waitt, Greg, Soderblom, Erik J., Barrington, Blake C., Asfaw, Yohannes G., Moseley, M. Arthur, Steinbach, William J.
Format: Artigo
Langue:Inglês
Publié: 2019
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6615987/
https://ncbi.nlm.nih.gov/pubmed/30927289
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/mmi.14254
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