Stable, Reactive and Orthogonal Tetrazines: Dispersion Forces Promote the Cycloaddition with Isonitriles

Bioorthogonal reactions are of great value in the life sciences. The isocyano group is a structurally compact bioorthogonal functional group that reacts with tetrazines under physiological conditions. Here we report that bulky tetrazine substituents accelerate this cycloaddition. Computational studi...

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Xehetasun bibliografikoak
Argitaratua izan da:Angew Chem Int Ed Engl
Egile Nagusiak: Tu, Julian, Svatunek, Dennis, Parvez, Saba, Liu, Albert C. G., Levandowski, Brian J., Eckvahl, Hannah J., Peterson, Randall T., Houk, Kendall N., Franzini, Raphael M.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2019
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC6615965/
https://ncbi.nlm.nih.gov/pubmed/31062496
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.201903877
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