Structural basis of resistance of mutant RET protein-tyrosine kinase to its inhibitors nintedanib and vandetanib

RET is a transmembrane growth factor receptor. Aberrantly activated RET is found in several types of human cancer and is a target for treating RET aberration-associated cancer. Multiple clinically relevant RET protein-tyrosine kinase inhibitors (TKIs) have been identified, but how TKIs bind to RET i...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Terzyan, Simon S., Shen, Tao, Liu, Xuan, Huang, Qingling, Teng, Peng, Zhou, Mi, Hilberg, Frank, Cai, Jianfeng, Mooers, Blaine H. M., Wu, Jie
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2019
Assuntos:
Protein Structure and Folding
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6615680/
https://ncbi.nlm.nih.gov/pubmed/31118272
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA119.007682
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