Protein kinase D and Gβγ mediate sustained nociceptive signaling by biased agonists of protease-activated receptor-2

Proteases sustain hyperexcitability and pain by cleaving protease-activated receptor-2 (PAR(2)) on nociceptors through distinct mechanisms. Whereas trypsin induces PAR(2) coupling to Gα(q), Gα(s), and β-arrestins, cathepsin-S (CS) and neutrophil elastase (NE) cleave PAR(2) at distinct sites and acti...

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Bibliographic Details
Published in:J Biol Chem
Main Authors: Zhao, Peishen, Pattison, Luke A., Jensen, Dane D., Jimenez-Vargas, Nestor N., Latorre, Rocco, Lieu, TinaMarie, Jaramillo, Josue O., Lopez-Lopez, Cintya, Poole, Daniel P., Vanner, Stephen J., Schmidt, Brian L., Bunnett, Nigel W.
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2019
Subjects:
Signal Transduction
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6615677/
https://ncbi.nlm.nih.gov/pubmed/31142616
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.006935
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