Characterization of two engineered dimeric Zika virus envelope proteins as immunogens for neutralizing antibody selection and vaccine design

The envelope protein of Zika virus (ZIKV) exists as a dimer on the mature viral surface and is an attractive antiviral target because it mediates viral entry. However, recombinant soluble wild-type ZIKV envelope (wtZE) might preferentially exist as monomer (monZE). Recently, it has been shown that t...

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Bibliographic Details
Published in:J Biol Chem
Main Authors: Yang, Chunpeng, Zeng, Fang, Gao, Xinyu, Zhao, Shaojuan, Li, Xuan, Liu, Sheng, Li, Na, Deng, Chenglin, Zhang, Bo, Gong, Rui
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2019
Subjects:
Protein Structure and Folding
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6615672/
https://ncbi.nlm.nih.gov/pubmed/31138647
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA119.007443
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