ZIKA-001: Safety and Immunogenicity of an Engineered DNA Vaccine against Zika virus infection

BACKGROUND: While Zika virus (ZIKV) infection is typically self-limited, congenital birth defects and Guillain-Barré syndrome are well-described. There are no approved ZIKV vaccines. METHODS: ZIKA-001, a phase I, open label, clinical trial evaluated the safety and immunogenicity of synthetic, consen...

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Udgivet i:N Engl J Med
Main Authors: Tebas, Pablo, Roberts, Christine C., Muthumani, Kar, Reuschel, Emma L., Kudchodkar, Sagar B., Zaidi, Faraz I., White, Scott, Khan, Amir S., Racine, Trina, Choi, Hyeree, Boyer, Jean, Park, Young K, Trottier, Sylvie, Remigio, Celine, Krieger, Diane, Spruill, Susan E., Kobinger, Gary P., Weiner, David B., Maslow, Joel N.
Format: Artigo
Sprog:Inglês
Udgivet: 2021
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6824915/
https://ncbi.nlm.nih.gov/pubmed/34525286
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1056/NEJMoa1708120
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