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Measuring intolerance to mutation in human genetics
In numerous applications, from working with animal models to mapping the genetic basis of human disease susceptibility, it is useful to know whether a single disrupting mutation in a gene is likely to be deleterious. With this goal in mind, a number of measures have been developed to identify genes...
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| Publicado no: | Nat Genet |
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| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6615471/ https://ncbi.nlm.nih.gov/pubmed/30962618 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41588-019-0383-1 |
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