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The population genetics of human disease: The case of recessive, lethal mutations
Do the frequencies of disease mutations in human populations reflect a simple balance between mutation and purifying selection? What other factors shape the prevalence of disease mutations? To begin to answer these questions, we focused on one of the simplest cases: recessive mutations that alone ca...
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| Publicado no: | PLoS Genet |
|---|---|
| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Public Library of Science
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5619689/ https://ncbi.nlm.nih.gov/pubmed/28957316 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1006915 |
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